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5 results
In Preparation
Marian Kalocsay, Matthew J. Berberich, Robert A. Everley, Maulik K. Nariya, Mirra Chung, Ben Gaudio, Chiara Victor, Gary A. Bradshaw, Marc Hafner, Peter K. Sorger, Caitlin E.Mills, and Kartik Subramanian. “Proteomic Profiling of Breast Cancer Cell Lines and Models”
Marian Kalocsay, Matthew J. Berberich, Robert A. Everley, Maulik K. Nariya, Mirra Chung, Ben Gaudio, Chiara Victor, Gary A. Bradshaw, Marc Hafner, Peter K. Sorger, Caitlin E.Mills, and Kartik Subramanian. “Proteomic Profiling of Breast Cancer Cell Lines and Models”
We performed quantitative proteomics on 61 human-derived breast cancer cell lines to a depth of ~13,000 proteins. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the datasets to identify and characterize the...
2024
Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matther G. Vander Heiden, and Peter K. Sorger. 2024. “A CRISPRi A Screening Platform to Study Cellular Nutrient Transport in Diverse Microenvironments”. Nature Cell Biology, 26, Pp. 825-38
Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matther G. Vander Heiden, and Peter K. Sorger. 2024. “A CRISPRi A Screening Platform to Study Cellular Nutrient Transport in Diverse Microenvironments”. Nature Cell Biology, 26, Pp. 825-38
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here we report a CRISPR interference/activation screening platform to systematically interrogate...
2022
Caitlin E.Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J. Nirmal, Nicholas Clark, and Peter K. Sorger. 2022. “Multiplexed and Reproducible High Content Screening of Live and Fixed Cells Using Dye Drop”. Nature Communications, 13, 6918
Caitlin E.Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J. Nirmal, Nicholas Clark, and Peter K. Sorger. 2022. “Multiplexed and Reproducible High Content Screening of Live and Fixed Cells Using Dye Drop”. Nature Communications, 13, 6918
2020
Jason Qian, Sarah A. Boswell, Christopher Chidley, Zhi-xiang Lu, Mary E. Pettit, Benjamin L. Gaudio, Jesse M. Fajnzylber, Ryan T. Ingram, Rebecca H. Ward, Jonathan Z. Li, and Michael Springer. 2020. “An Enhanced Isothermal Amplification Assay for Viral Detection”. Nature Communications
Jason Qian, Sarah A. Boswell, Christopher Chidley, Zhi-xiang Lu, Mary E. Pettit, Benjamin L. Gaudio, Jesse M. Fajnzylber, Ryan T. Ingram, Rebecca H. Ward, Jonathan Z. Li, and Michael Springer. 2020. “An Enhanced Isothermal Amplification Assay for Viral Detection”. Nature Communications
Rapid, inexpensive, robust diagnostics are essential to control the spread of infectious diseases. Current state of the art diagnostics are highly sensitive and specific, but slow, and require expensive equipment. We developed a molecular diagnostic test...
2019
Mario Niepel, Marc Hafner, Caitlin E.Mills, Kartik Subramanian, Elizabeth H. Williams, Mirra Chung, Benjamin Gaudio, and Anne Marie Barrett. 2019. “A Multi-Center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines”. Cell Systems, 9, 1, Pp. 35-48
Mario Niepel, Marc Hafner, Caitlin E.Mills, Kartik Subramanian, Elizabeth H. Williams, Mirra Chung, Benjamin Gaudio, and Anne Marie Barrett. 2019. “A Multi-Center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines”. Cell Systems, 9, 1, Pp. 35-48
Evidence that some high-impact biomedical results cannot be repeated has stimulated interest in practices that generate findable, accessible, interoperable, and reusable (FAIR) data. Multiple papers have identified specific examples of irreproducibility...